Random Clincal Trials

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NCT04201072: Probiotics and Gut Microbiome in Type 2 Diabetes** (2021, 120 participants)  
This randomized controlled trial showed that a 12-week probiotic intervention improved gut microbiota diversity, reduced inflammation markers (like CRP), and lowered HbA1c by 0.8% in T2D patients—proving digestion tweaks stabilize blood sugar and fight metabolic disease.


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Exploring the Impact of the Gut Microbiome on Obesity and Weight Loss: A Review Article
by J Noor2023Cited by 34 — Several studies have shown that probiotics can reduce BMI and total body fat, especially visceral fat [38]

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The association of weight loss with changes in the gut microbiota diversity, composition, and intestinal permeability: a systematic review and meta-analysi
. 2022 Jan 18;14(1):2020068. doi: 10.1080/19490976.2021.2020068

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NCT04545029: Prebiotic Fiber Supplementation for Inflammatory Bowel Disease** (2023, 150 participants)  
Over 12 weeks, participants saw 50% less gut inflammation (via calprotectin levels) and better immune function, delaying IBD flares. Key takeaway: Targeted gut repair stops chronic disease progression.

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NCT01222104 ClinicalTrials.gov:  A randomized trial of a low-FODMAP diet in IBS” (diet intervention affecting gut symptoms and inflammatory markers in some designs)  Focus: Dietary change to reduce fermentation/gas and downstream gut irritation; some protocols also track inflammation-related measures.


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Gut microbiota’s effect on mental health: The gut-brain axis” (ClinicalTrials.gov)  
A study looking at whether changing the gut microbiome (often via probiotics/prebiotics/diet) can impact mood outcomes like depression/anxiety symptoms.

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Probiotic supplementation for Major Depressive Disorder” (ClinicalTrials.gov)  
A randomized clinical trial evaluating whether a specific probiotic formula improves depression scores compared to placebo.

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Dietary intervention (Mediterranean-style / anti-inflammatory diet) for depression with gut microbiome outcomes” (ClinicalTrials.gov)  
A trial testing whether improving diet quality changes both depressive symptoms and gut-related markers (microbiome/inflammation).

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Leaky gut and autoimmune diseases”
Journal: Clinical Reviews in Allergy & Immunology (2012)
Authors: Arrieta, Bistritz, Meddings